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Thus, there were increased intraocular pressure and mydriasis, degeneration of retinal ganglion cells, optic nerve head excavation and reduction in optic nerve thickness, generalized severe irregularity of retinal vessels, faint presentation of choroidal vessels, and severe optic nerve disc atrophy in glaucomatous rats [11]
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Furthermore, upregulation of voltage-gated Ca 2+ channels (VGCCs), particularly CaV1.3, promotes resistance to androgen deprivation therapy (ADT) and the progression of castration-resistant prostate cancer (CRPC) [32]
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